Electroactive Artificial Muscles Based on Functionally Antagonistic Core–Shell Polymer Electrolyte Derived from PS-b-PSS Block Copolymer

Electroactive ionic soft actuators, a type of artificial muscles containing a polymer electrolyte membrane sandwiched between two electrodes, have been intensively investigated owing to their potential applications to bioinspired soft robotics, wearable electronics, and active biomedical devices. However, the design and synthesis of an efficient polymer electrolyte suitable for ion migration have been major challenges in developing high-performance ionic soft actuators. Herein, a highly bendable ionic soft actuator based on an unprecedented block copolymer is reported, i.e., polystyrene-b-poly(1-ethyl-3-methylimidazolium-4-styrenesulfonate) (PS-b-PSS-EMIm), with a functionally antagonistic core–shell architecture that is specifically designed as an ionic exchangeable polymer electrolyte. The corresponding actuator shows exceptionally good actuation performance, with a high displacement of 8.22 mm at an ultralow voltage of 0.5 V, a fast rise time of 5 s, and excellent durability over 14 000 cycles. It is envisaged that the development of this high-performance ionic soft actuator could contribute to the progress toward the realization of the aforementioned applications. Furthermore, the procedure described herein can also be applied for developing novel polymer electrolytes related to solid-state lithium batteries and fuel cells

KpqBench: Performance and Implementation Security Analysis of KpqC Competition Round 1 Candidates

As the global migration to post-quantum cryptography (PQC) continues to progress actively, in Korea, the Post-Quantum Cryptography Research Center has been established to acquire PQC technology, leading the KpqC Competition. In February 2022, the KpqC Competition issued a call for proposals for PQC algorithms. By November 2022, 16 candidates were selected for the first round (7 KEMs and 9 DSAs). Currently, Round 1 submissions are being evaluated with respect to security, efficiency, and scalability in various environments. At the current stage, evaluating the software through an analysis to improve the software quality of the first-round submissions is judged appropriately. In this paper, we present analysis results regarding performance and implementation security on based dependency-free approach of external libraries. Namely, we configure extensive tests for an analysis with no dependencies by replacing external libraries that can complicate the build process with hard coding. From the performance perspective, we provide analysis results of performance profiling, execution time, and memory usage for each of the KpqC candidates. From the implementation security perspective, we examine bugs and errors in the actual implementations using Valgrind software, a metamorphic testing methodology that can include wide test coverage and constant-time implementation against the timing attack. Until the KpqC standard algorithm is announced, we argue that continuous integration of extensive tests will lead to higher-level software quality of KpqC candidates

Fabricating High-Resolution and High-Dimensional Microneedle Mold through the Resolution Improvement of Stereolithography 3D Printing

Microneedles are transdermal drug delivery tools that can be fabricated simply, economically, and rapidly using SLA 3D printing. However, SLA 3D printing has a limitation in that the resolution is slightly lowered when the microneedle is precisely printed. To solve this issue, we optimized the SLA 3D printing conditions such as printing angle, needle height, aspect ratio, and spacing between the microneedles for high-resolution microneedle fabrication. The sharpest microneedle tip was obtained when the printing angle was adjusted to 60° in both the x and y axes. The aspect ratio and the spacing between the microneedles did not affect the output of the sharp tip. Under optimal conditions, the microneedles with 1180 ± 20 µm height, 490 ± 20 µm base, and 30.2 ± 3.4 µm tip diameter were obtained. The dissolving microneedle patch, prepared using the 3D printed microneedle as a mold, penetrated the porcine skin ex vivo. When the printing angle was 60° in the x and y axes, the area of the single stacking layer, including the microneedle tip, increased, and thus the sharp tip could be printed. A high-dimensional, side-notched arrowhead (SNA) microneedle was fabricated by applying the SLA 3D printing condition. Moreover, a letter-type microneedle patch was fabricated using the customized characteristics of 3D printing. Consequently, high-resolution and high-dimensional microneedles were successfully fabricated by adjusting the printing angle using a general SLA 3D printer, and this technology will be applied to the manufacture of drug delivery tools and various microstructures

Evaluation of the Reverse Mortgage Option in Korea: A Long Straddle Perspective

This study explored the option value embedded in a reverse mortgage in Korea through an empirical analysis, using the Black–Scholes option-pricing model. The value of a reverse mortgage is affected by the variation in house prices. However, older homeowners using reverse mortgages are able to choose this option due to the unique characteristics of reverse mortgages, such as non-recourse clauses or being able to redeem the loan. This paper found the following results. First, the call option value is 5.8% of the house price at the age of 60, under the assumption of a KRW three hundred million house value, while the put option value is only 2.0%. Contrary to what it is at sixty years of age, only the call option value will remain when the homeowner reaches the age of 80. Second, this article analyzed the sensitivity of the key variables of real-option analytical models, such as the change of the exercise price, the change of the risk-free rate, volatility, and maturity, on the option value of a reverse mortgage. The sensitivity results of the key variables supported economic rationales for the option pricing model

Mathematical Modeling and Analysis of Chemotherapy Strategy in the Treatment of HIV

The World Health Organization has reported that Acquired Immune Deficiency Syndrome (AIDS) has been found to be the second leading cause of death by diseases. Therefore, the importance of treating the disease has been greatly emphasized. These days, scientists have suggested that chemotherapy could be the most effective way of treating AIDS. We built a mathematical model of dynamics of the Human Immunodeficiency Virus (HIV) through a system of differential equations, which describes the interactions between the HIV and T-cells that are immune cells attacked by the HIV. The model produced the concentration rate of infected and uninfected T-cells over time when there is a medical intervention, called chemotherapy. We mathematically analyzed the dynamics of the immune system and the HIV and performed the computer simulations for various chemotherapy strategies

Local ocular factors associated with the development of diabetic macular edema: an inter-eye study

Abstract To investigate local ocular factors associated with the development of diabetic macular edema (DME), we classified each eye of patients with unilateral DME as the DME eyes or the fellow eyes (without DME). We compared the clinical characteristics, optical coherence tomography (OCT), and OCT angiography (OCTA), ultra-wide field fundus photography, and angiography features of each eye. As a result, fifty-five patients with unilateral DME were enrolled. Although the diabetic retinopathy stage was not different between each group of eyes, DME eyes showed a higher prevalence of venous beading and a larger area of nonperfusion region than did fellow eyes (all P < 0.05). OCTA features of DME eyes also showed a larger foveal avascular zone in the deep capillary plexus and a lower vascular density in both the superficial and deep capillary plexuses (all P < 0.05). This study highlighted ocular features reflecting retinal ischemia, such as venous beading, area of nonperfusion region, and vascular density in the central retinal area, are associated with the development of DME. OCTA and ultra-wide field fluorescein angiography may be useful for evaluating the parameters of retinal ischemia and the risk of DME development

Protective coating of strawberries with cellulose nanofibers

Since shelf life of perishable foods is short, a compelling challenge is to prolong the freshness of foods with a costeffective strategy. A perishable fruit, the strawberry, is chosen as a model perishable food and an edible film coating is applied to it using carboxymethylated cellulose nanofibers (CM-CNFs) stabilized by cationic salts. A transparent and impermeable CM-CNF film is formed at the strawberry surface using a dip coating process. The formation of the film is dependent on the electrostatic interaction between anionic CM-CNF and salt cations. Physical properties of the film are characterized and the effectiveness of edible film coating on the freshness of perishable fruit is evaluated by the measurement of weight loss, CO2 release, firmness, total solid sugar and acidity. Cellulose nanofiber is a promising cost-effective material appropriate for use as an edible coating that contributes to the long-term storage and prolonged freshness of foods.N

Durable and Water-Floatable Ionic Polymer Actuator with Hydrophobic and Asymmetrically Laser-Scribed Reduced Graphene Oxide Paper Electrodes

Ionic polymer actuators driven by electrical stimuli have been widely investigated for use in practical applications such as bioinspired robots, sensors, and biomedical devices. However, conventional ionic polymer–metal composite actuators have a serious drawback of poor durability under long-term actuation in open air, mainly because of the leakage of the inner electrolyte and hydrated cations through cracks in the metallic electrodes. Here, we developed a highly durable and water-floatable ionic polymer artificial muscle by employing hydrophobic and asymmetrically laser-scribed reduced graphene oxide paper electrodes (HLrGOP). The highly conductive, flexible, and cost-effective HLrGOP electrodes have asymmetrically smooth hydrophobic outer and rough inner surfaces, resulting in liquid-impermeable and water-floatable functionalities and strong bonding between an ionic polymer and the electrodes. More interestingly, the HLrGOP electrode, which has a unique functionality to prevent the leakage of the vaporized or liquid electrolyte and mobile ions during electrical stimuli, greatly contributes to an exceptionally durable ionic polymer–graphene composite actuator that is a prerequisite for practical applications in active biomedical devices, biomimetic robots, touch-feedback haptic systems, and flexible soft electronics

Characterization of MAGEG2 with testis-specific expression in mice

Male germ cell development is a well-defined process occurring in numerous seminiferous tubules of the testis. Uncovering testicular novel genes related to intrinsic regulation of spermatogenesis is essential for the understanding of spermatogenesis. In the present study, we investigated mouse Mageg2, which belongs to a group of melanoma-associated antigens (MAGEs). Mageg2 is transcribed in the testis specifically, and its expression level is increased at the pachytene spermatocyte stage, indicating that Mageg2 is expressed predominantly in germ cells. We generated an antibody against mouse MAGEG2 for further characterization at the protein level. Immunoblot analysis suggested that MAGEG2 has specific testicular expression and the expression primarily occurred in pachytene spermatocytes. Proteomic analyses demonstrated that mouse MAGEG2 binded to testicular germ cell-specific serine/threonine-protein kinase 31 (STK31) and heat shock protein 9 (HSPA9). Direct binding with both interaction partners was confirmed by co-immunoprecipitation. We found that STK31 and HSPA9 bind MAGEG2 directly but not with each other. Interestingly, MAGEG2 reduced the kinase activity of STK31. Our study suggests that mouse MAGEG2 has at least two functions, including chaperone activity related to HSPA9 and regulation of pachytene spermatocyte-specific kinase, STK31. Altogether, our results provide the first information about MAGEG2 at the transcript and protein levels and suggest its potential molecular functions

BER performance degradation of MMoF system due to impairments in optical SSB link

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